Celiac musings

This study shows that, surprise surprise, there is a distribution of sensitivity to gluten amongst celiacs.

If there wasn’t one I’d be astonished.

I guess the only practical outcomes from this study are these unanswered questions:

Is there a threshold of immune response at which someone is classified as having celiac disease, or is the diagnosis based on a broader combination of genetics, antibodies, intestinal damage and clinical history? If it is based on a threshold, where should that threshold sit?
Are all humans sensitive to gluten if the dose is high enough, with celiac disease simply representing the extreme end of the distribution? That is, is celiac disease fundamentally a general consequence of consuming a sufficiently large amount of gluten? Eventually even the fatman gets a immune response?